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Institute of Molecular Biology Institute of Molecular Biology
Division of Natural Sciences

Antiviral agents against African swine fever virus

N Investment project title Antiviral agents against African swine fever virus
1. Sector

Agriculture, veterinary, biotechnology

2. Project description

African swine fever virus (ASFV) is the causative agent of a highly contagious hemorrhagic disease of domestic and wild pigs. Highly virulent ASFV strains cause 100% mortality in affected herds. Due to the lack of effective vaccines, ASFV has devastating socioeconomic impact on pig farming industry. It has been discovered that two plant-derived compounds, apigenin and genistein, exert potent antiviral activity against ASFV, targeting different stages of viral life cycle. Apigenin is able to reduce the ASFV yield by 1000 times (3 log). This compound is highly effective, when it is added at early hours post-infection. Apigenin inhibits the synthesis of viral DNA and proteins. Genistein inhibits ASFV DNA replication by targeting the ATPbinding site of viral topoisomerase II enzyme. As a result, genistein impairs the function of viral enzyme leading to the decrease in viral yield by more than 3 log. Since the ATP-binding site is highly conserved in different ASFV strains, it may serve as a good target for further antiviral drug discovery and development.

3. Project implementation period 3 years
4. Project location Institute of Molecular Biology of NAS RA
5. Project overall cost (USD) 200.000
6. Required investments (USD) 175.000
7. Own funds (USD) 25.000 (has been already invested in R&D and preliminary trials)
8. Creation of jobs At the beginning of the project At the end of the project
4 30
9. Payback period 5 - 7 years
10. Annual profitability index -
11. Detailed costs

-

12. Offer to investor

The organization of a joint venture, an investor’s share will depend on the amount of invested funds and project involvement stage

13. Contact details

Arsen Arakelyan, Director of the Institute of Molecular Biology of NAS RA
E-mail: aarakelyan {[ at ]} sci.am
Tel.: (+374 10) 281626



Reduction of ASFV yield upon treatment with different concentrations of apigenin
Reduction of ASFV yield upon treatment with different concentrations of apigenin
Viral DNA in the presence of apigenin after long-term treatment
Viral DNA in the presence of apigenin after long-term treatment
Interaction of genistein with the ATP-binding site of topo II enzyme
Interaction of genistein with the ATP-binding site of topo II enzyme

Notices








The Institute of Physical Research of NAS of Armenia in collaboration with the IPR Armenia Optica Student Chapter have announced a photo contest entitled "Light through the Eyes of a Photographer" dedicated to the International Day of Light. The registration deadline for the competition is May 1

Ս.թ. ապրիլի 10-ին ժ. 15:00-ին ՀՀ ԳԱԱ նիստերի դահլիճում (Բաղրամյան պող., 24) տեղի կունենա սեմինարների շարքի երրորդ հանդիպումը՝ «Հավաքում ենք փաթիլ. ատոմներից դեպի մոլեկուլ և բյուրեղ» խորագրով: Որպես մոդերատոր հանդես կգա անվանի քիմիկոս, SKOLKOVO-ի գիտության և տեխնոլոգիաների ինստիտուտի պրոֆեսոր Արտեմ Օհանովը

On April 5 2024, a seminar on the topic "Advanced channeling Technologies: Strong external Electromagnetic fields to guide charged and Neutral Beams" will be held at the conference hall of the NAS RA Presidum which will be presented by professor of the Institute of Nuclear Physics (Italy) Sultan Dabagov

On April 1st 2024, a seminar on the topic "Magnetometry with nuclear spin-polarized 14N in NV centers in diamond" will be held at the conference hall of the RA NAS Presidium which will be presented by professor of the University of Latvia Marcis Auzinsh

The Shirak Center for Armenological Studies of NAS RA is starting to publish the 1 (27) volume of the "Scientific Works" journal for 2024. Priority is given to articles in English and Russian. The deadline for receiving articles is March 1, 2024

Международный инновационный центр нанотехнологий СНГ (МИЦНТ СНГ) при поддержке Межгосударственного фонда гуманитарного сотрудничества государств - участников СНГ (МФГС) и Объединенного института ядерных исследований объявляет о проведении конкурса на соискание грантов на разработку проектов в рамках деятельности МИЦНТ СНГ в 2024 году и очередной Стажировки молодых ученых и специалистов стран СНГ в Дубне в апреле - мае 2024года

ՀՀ գիտության և տեխնիկայի զարգացման 2020-2024թթ. գերակայության ՀՀ կառավարության որոշման նախագիծ

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