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Institute of Physiology after L.A. Orbeli Institute of Physiology after L.A. Orbeli
Division of Natural Sciences

Creation and cultivation of functional skin tissue suitable for transplantation with the use of mesenchymal stem cells

N Investment project title Creation and cultivation of functional skin tissue suitable for transplantation with the use of mesenchymal stem cells
1. Sector

Regenerative medicine

2. Project description

Regenerative medicine has already begun to produce complex skin, cartilage, and bone substitutes for clinical use in many countries, including the US, EU, Japan, China, and Australia. It may be the right time for Armenia to take advantage of its own resources and scientific potential to develop such a program by creating a national center on tissue engineering and regenerative medicine in order to establish itself as a regional leader in the field. No such centers exist regionally; currently, the closest tissue engineering labs are located in Moscow, Russia, and Ankara, Turkey. Large skin defects resulting from burns, trauma, diabetic ulcers, and congenital disease can lead to skin necrosis and can certainly represent a challenge to achieving skin coverage. Today, a number of tissue-engineered skin substitutes are available commercially in the US and Europe (but not in Armenia or in the region).Biological skin substitutes (such as allografts or xenografts) are similar to the skin, with an intact and native extracellular matrix, allowing the restoration of a more natural, new dermis. They also support re-epithelialization due to the presence of a basement membrane. The most widely used biological substitutes worldwide are porcine or cadaveric skin. Recently, it has been shown that excised excess skin from plastic surgery procedures can also serve as an effective source of biological skin substitutes or can be decellularized to serve as a scaffold to seed a patient’s own cells.

3. Project implementation period 3 years
4. Project location L.Orbeli Institute of Physiology of NAS RA
5. Project overall cost (USD) 445.000
6. Required investments (USD) 345.000
7. Own funds (USD) 100.000
8. Creation of jobs At the beginning of the project At the end of the project
5 12
9. Payback period 4 years
10. Annual profitability index Min USD 240.000
11. Detailed costs

-

12. Offer to investor

According to the American Burn Association there are about 150.000 hospitalizations for burns in the US annually; in about a third of these cases the patients receive a skin graft, i.e. there are some 50.000 skin grafting procedures annually for burns in the US. The total incidence of skin grafting is much greater than the incidence of severe burns since it is also used for the treatment of chronic ulcers and skin replacement due to injury from other causes. Again, using very conservative estimates, one can assess the total expected number of skin graft procedures in Armenia to be around 1000 (including chronic ulcers, burns, trauma, etc). Assuming that the cost of the 10x10cm2 graft is about USD 300- USD 500, these procedures would bring in a revenue of about USD 300-500 thousand annually.

13. Contact details

Zaruhi Karabekian, Head of the Laboratory of Tissue Engineering of L.Orbeli Institute of Physiology of NAS RA 
E-mail: zkarabekian {[ at ]} yahoo.com
Tel.: (+374 10) 272247 
(Co-author of the project: Dr., Prof. Narine Sarvazyan, GW Schools of Medicine and Engineering, USA)




Notices








On April 23, 2024, at 10:30, the Annual General Meeting of NAS RA on the main results of the scientific and scientific-organizational activity of the National Academy of Sciences of the Republic of Armenia for 2023 will be held. The Annual General Meetings of the Divisions of Sciences will be held on April 22 at 10:00

The Institute of Physical Research of NAS of Armenia in collaboration with the IPR Armenia Optica Student Chapter have announced a photo contest entitled "Light through the Eyes of a Photographer" dedicated to the International Day of Light. The registration deadline for the competition is May 1

Ս.թ. ապրիլի 10-ին ժ. 15:00-ին ՀՀ ԳԱԱ նիստերի դահլիճում (Բաղրամյան պող., 24) տեղի կունենա սեմինարների շարքի երրորդ հանդիպումը՝ «Հավաքում ենք փաթիլ. ատոմներից դեպի մոլեկուլ և բյուրեղ» խորագրով: Որպես մոդերատոր հանդես կգա անվանի քիմիկոս, SKOLKOVO-ի գիտության և տեխնոլոգիաների ինստիտուտի պրոֆեսոր Արտեմ Օհանովը

On April 5 2024, a seminar on the topic "Advanced channeling Technologies: Strong external Electromagnetic fields to guide charged and Neutral Beams" will be held at the conference hall of the NAS RA Presidum which will be presented by professor of the Institute of Nuclear Physics (Italy) Sultan Dabagov

On April 1st 2024, a seminar on the topic "Magnetometry with nuclear spin-polarized 14N in NV centers in diamond" will be held at the conference hall of the RA NAS Presidium which will be presented by professor of the University of Latvia Marcis Auzinsh

The Shirak Center for Armenological Studies of NAS RA is starting to publish the 1 (27) volume of the "Scientific Works" journal for 2024. Priority is given to articles in English and Russian. The deadline for receiving articles is March 1, 2024

Международный инновационный центр нанотехнологий СНГ (МИЦНТ СНГ) при поддержке Межгосударственного фонда гуманитарного сотрудничества государств - участников СНГ (МФГС) и Объединенного института ядерных исследований объявляет о проведении конкурса на соискание грантов на разработку проектов в рамках деятельности МИЦНТ СНГ в 2024 году и очередной Стажировки молодых ученых и специалистов стран СНГ в Дубне в апреле - мае 2024года

ՀՀ գիտության և տեխնիկայի զարգացման 2020-2024թթ. գերակայության ՀՀ կառավարության որոշման նախագիծ

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