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Institute of Physiology after L.A. Orbeli Institute of Physiology after L.A. Orbeli
Division of Natural Sciences

Macrovipera Lebetina Obtusa and other endemic viper venom antiserum production

N Investment project title Macrovipera Lebetina Obtusa and other endemic viper venom antiserum production
1. Sector

Pharmacology

2. Project description

Using a similarity coefficient we have estimated that the similarity of venom proteins between the two Macrovipera lebetina populations of Former Soviet Union (M.l. obtusa and M.l. turanica) is less than 4%, and is mainly restricted to the group of dimeric disintegrins. Therefore, although our comparative proteomic analysis would support the classification of M.l. obtusa and M.l. transmediterranea as different species, additional detailed genomic analyses are also required to address this point and to assess whether their distinct venom protein profiles arise from expression of population-specific genes or from distinct translation patterns of the same genome. However, specific antivenom is available only for some Middle Asian snake species, including M.l. turanica but not M.l. obtusa or V. raddei. Currently, the only one antivenom product is available in Armenia from Uzbekistan, which contains the antibodies not only against Middle Asian gjurza venom (M.l. turanica), but also antibodies against cobra (Naja oxiana) and efa (Echis carinatus). This antiserum is a very allergic treatment for patients, so it could cause a number of hard side-effects, and moreover, it is very expensive for our clinics (140 000AMD per one 10ml vial). Besides the viper venom antiserum, we could manufacture also single toxins from venom composition, which are unique proteins with wide range of applications in biochemical analysis, and some Armenian analogs of classical known pharmaceutical products with viper venom (like as Viprosal B, (Tallin); price – 1750AMD; etc.).

3. Project implementation period 3 years
4. Project location L.Orbeli Institute of Physiology of NAS RA
5. Project overall cost (USD) 518.000
6. Required investments (USD) 368.000
7. Own funds (USD) 150.000
8. Creation of jobs At the beginning of the project At the end of the project
15 21
9. Payback period 2 years
10. Annual profitability index Min USD 180.000
11. Detailed costs

-

12. Offer to investor

Due to protocols of WHO Guidelines for the Production, Control and Regulation of Snake Antivenom Immunoglobulins (Geneve, Switzerland, 2010) from 15mg of solid venom after 8 weeks of immunization of equines we could have the 15l of antiserum (therefore – 1500 vial with 10 ml of antivenom each). Even the realization of this pilot series of product among the registered net of 129 clinics and 514 ambulance-policlinics with low cost of 50 000 AMD per vial could return the 1/4-rd of the investment.
Additionally, this product is extremely necessary in Military hospitals, because the Military servants are the snakebites’ target groups N1 in our country.

13. Contact details

Naira Ayvazyan, Director of L.Orbeli Institute of Physiology of NAS RA
E-mail: taipan {[ at ]} ysu.am
Tel.: (+374 10) 272247; (+374 91) 587344




Notices








On 15 May 2024, at 14.00 a seminar on the topic "Astronomy in the crossroads of multidisciplinary and interdisciplinary sciences" will be held at the conference hall of Presidium of the NAS RA, which will be presented by the director of the Byurakan Astrophysical Observatory after V. Ambartsumian, cand.(phys.-math.) Areg Mickaelian

On April 23, 2024, at 10:30, the Annual General Meeting of NAS RA on the main results of the scientific and scientific-organizational activity of the National Academy of Sciences of the Republic of Armenia for 2023 will be held. The Annual General Meetings of the Divisions of Sciences will be held on April 22 at 10:00

The Institute of Physical Research of NAS of Armenia in collaboration with the IPR Armenia Optica Student Chapter have announced a photo contest entitled "Light through the Eyes of a Photographer" dedicated to the International Day of Light. The registration deadline for the competition is May 1

Ս.թ. ապրիլի 10-ին ժ. 15:00-ին ՀՀ ԳԱԱ նիստերի դահլիճում (Բաղրամյան պող., 24) տեղի կունենա սեմինարների շարքի երրորդ հանդիպումը՝ «Հավաքում ենք փաթիլ. ատոմներից դեպի մոլեկուլ և բյուրեղ» խորագրով: Որպես մոդերատոր հանդես կգա անվանի քիմիկոս, SKOLKOVO-ի գիտության և տեխնոլոգիաների ինստիտուտի պրոֆեսոր Արտեմ Օհանովը

On April 5 2024, a seminar on the topic "Advanced channeling Technologies: Strong external Electromagnetic fields to guide charged and Neutral Beams" will be held at the conference hall of the NAS RA Presidum which will be presented by professor of the Institute of Nuclear Physics (Italy) Sultan Dabagov

On April 1st 2024, a seminar on the topic "Magnetometry with nuclear spin-polarized 14N in NV centers in diamond" will be held at the conference hall of the RA NAS Presidium which will be presented by professor of the University of Latvia Marcis Auzinsh

The Shirak Center for Armenological Studies of NAS RA is starting to publish the 1 (27) volume of the "Scientific Works" journal for 2024. Priority is given to articles in English and Russian. The deadline for receiving articles is March 1, 2024

Международный инновационный центр нанотехнологий СНГ (МИЦНТ СНГ) при поддержке Межгосударственного фонда гуманитарного сотрудничества государств - участников СНГ (МФГС) и Объединенного института ядерных исследований объявляет о проведении конкурса на соискание грантов на разработку проектов в рамках деятельности МИЦНТ СНГ в 2024 году и очередной Стажировки молодых ученых и специалистов стран СНГ в Дубне в апреле - мае 2024года

ՀՀ գիտության և տեխնիկայի զարգացման 2020-2024թթ. գերակայության ՀՀ կառավարության որոշման նախագիծ

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