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Scientific Results
01/03/2022
An immunogenetic variant, predicting a severe course of COVID-19, has been discovered in the Armenian Population

As a result of collaborative efforts of the staff members of the Institute of Molecular Biology of the National Academy of Sciences of the Republic of Armenia, the Armenian Bone Marrow Donor Registry Charitable Trust  and  "ClinSoft" LLC, an association between common HLA-C * 04:01 allele and COVID-19 severity has been revealed in Armenians.

Corroborating a significant role of other factors, such as male sex and an advanced age, in the severity of the disease in the Armenian population, the results of the study strongly suggest that HLA-C*04:01 allelic-load contributes to the risk for the severe COVID-19 independently from age and other HLA variables.

"The absence of the HLA-C*04:01 variant predicts asymptomatic course of the disease for the majority of the population, while homozygote carriage of this variant disrupts the recognition of coronavirus by the immune-competent cells and impedes the formation of an adequate immune response in time. The delay period is used by coronavirus for multiplication, which contributes to the severe course of the disease," said Karine Mayilyan, a senior scientific staff of the Laboratory of Human Genomics of the Institute of Molecular Biology of NAS RA.

"The research included more than 3,000 DNA sequences of Armenian residents. Based on HLA-C genotype and demographic variables, an algorithm has been developed for assessing the risk of the severe course of the disease, which can serve as a prognostic application in the medical practice" said Anahit Hovhannisyan, a scientific staff of the Laboratory of Evolutionary Genomics of the Institute of Molecular Biology of NAS RA.

"From the point of view of public health, this important result justifies the necessity for primary vaccination of the target group against COVID-19, which will prevent the severe course of the disease," said Arsen Arakelyan, the Director of the Institute.

The results of the study were published in the prestigious scientific journal "Frontiers in Immunology" (Hovhannisyan A, Madelian V, Avagyan S, Nazaretyan M, Hyussyan A, Sirunyan A, Arakelyan R, Manukyan Z, Yepiskoposyan L, Mayilyan KR, Jordan F. HLA-C * 04:01 Affects HLA Class I Heterozygosity and Predicted Affinity to SARS-CoV-2 Peptides, and in Combination With Age and Sex of Armenian Patients Contributes to COVID-19 Severity.Front Immunol.2022 Feb 3; 13: 769900.doi: 10.3389 /fimmu.2022.769900).


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NCP_WIDERA.NET Workshop on Horizon Europe will be organized on September 8, 2023, through 10:00 AM – 14:00 PM by the Scientific and Innovation Partnership Assistance Center (SIPAC) in cooperation with International Relations Department of NAS RA

On September 12 at 10:30 AM, in the Session Hall of the Presidium of NAS RA, Professor Miguel Rodriguez from the Madrid Institute for Glass and Ceramics will deliver a lecture

On September 12-15, 2023 the Institute for Physical Research (IPR) of National Academy of Sciences of Armenia organizes the annual International Conference on Laser Physics (LP - 2023) which will be dedicated to the 100th anniversary of the founder of the Institute for Physical Research, Professor Mikael Ter-Mikaelyan and the 80th anniversary of the foundation of the National Academy of Sciences of Armenia

On 18-22 of September 2023, the Institute of Applied Problems of Physics of NAS RA and YSU organize a joint RREPS-23 XIV International symposium "Radiation of relativistic electrons in periodic structures" and Meghri-23 VIII International conference "Electron, positron, neutron and X-ray scattering under the external influences" in Tsaghkadzor, dedicated to the 80th anniversary of NAS RA. For more information see: https://conference.iapp.am

On September 24-28, the international scientific conference "New emerging trends in chemistry" will be held in Yerevan

On 25–30 September, 2023 NAS RA and Institute for Informatics and Automation problems of NAS RA organize the 14th International Conference on "Computer Science and Information Technologies - CSIT-2023" (Yerevan, Armenia), dedicated to 80th anniversary of NAS RA. For more information see: https://csit.am/2023/

The 31st International Conference of the Functional Food Center will take place at the Matenadaran from September 29th - October 1st, 2023 (In-person with a virtual option). This conference will bring together experts in medicine, biology, and the food industry

On 1-5 October, 2023, Institute of Mechanics of NAS RA, National Committee on Theoretical and Applied Mechanics of Armenia, Ishlinsky Institute for Problems in Mechanics of the Russian Academy of Sciences, Southern Federal University (Rostov-on-Don, Russia), National University of Architecture and Construction of Armenia, Tsakhkadzor Writers House organize VIII International Conference on "Topical Problems of Continuum Mechanics" (Tsakhkadzor, Armenia). For more information see http://www.mechins.sci.am

ՀՀ կառավարությունը հաստատել է 2022 թվականին իրականացվելիք գիտական և գիտատեխնիկական պետական նպատակային ծրագրերը

ՀՀ գիտության և տեխնիկայի զարգացման 2020-2024թթ. գերակայության ՀՀ կառավարության որոշման նախագիծ

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1lurer.am
04/09/2023

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ankakh.com
31/08/2023

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