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Scientific Results
01/03/2022
An immunogenetic variant, predicting a severe course of COVID-19, has been discovered in the Armenian Population

As a result of collaborative efforts of the staff members of the Institute of Molecular Biology of the National Academy of Sciences of the Republic of Armenia, the Armenian Bone Marrow Donor Registry Charitable Trust  and  "ClinSoft" LLC, an association between common HLA-C * 04:01 allele and COVID-19 severity has been revealed in Armenians.

Corroborating a significant role of other factors, such as male sex and an advanced age, in the severity of the disease in the Armenian population, the results of the study strongly suggest that HLA-C*04:01 allelic-load contributes to the risk for the severe COVID-19 independently from age and other HLA variables.

"The absence of the HLA-C*04:01 variant predicts asymptomatic course of the disease for the majority of the population, while homozygote carriage of this variant disrupts the recognition of coronavirus by the immune-competent cells and impedes the formation of an adequate immune response in time. The delay period is used by coronavirus for multiplication, which contributes to the severe course of the disease," said Karine Mayilyan, a senior scientific staff of the Laboratory of Human Genomics of the Institute of Molecular Biology of NAS RA.

"The research included more than 3,000 DNA sequences of Armenian residents. Based on HLA-C genotype and demographic variables, an algorithm has been developed for assessing the risk of the severe course of the disease, which can serve as a prognostic application in the medical practice" said Anahit Hovhannisyan, a scientific staff of the Laboratory of Evolutionary Genomics of the Institute of Molecular Biology of NAS RA.

"From the point of view of public health, this important result justifies the necessity for primary vaccination of the target group against COVID-19, which will prevent the severe course of the disease," said Arsen Arakelyan, the Director of the Institute.

The results of the study were published in the prestigious scientific journal "Frontiers in Immunology" (Hovhannisyan A, Madelian V, Avagyan S, Nazaretyan M, Hyussyan A, Sirunyan A, Arakelyan R, Manukyan Z, Yepiskoposyan L, Mayilyan KR, Jordan F. HLA-C * 04:01 Affects HLA Class I Heterozygosity and Predicted Affinity to SARS-CoV-2 Peptides, and in Combination With Age and Sex of Armenian Patients Contributes to COVID-19 Severity.Front Immunol.2022 Feb 3; 13: 769900.doi: 10.3389 /fimmu.2022.769900).


Notices








On April 23, 2024, at 10:30, the Annual General Meeting of NAS RA on the main results of the scientific and scientific-organizational activity of the National Academy of Sciences of the Republic of Armenia for 2023 will be held. The Annual General Meetings of the Divisions of Sciences will be held on April 22 at 10:00

The Institute of Physical Research of NAS of Armenia in collaboration with the IPR Armenia Optica Student Chapter have announced a photo contest entitled "Light through the Eyes of a Photographer" dedicated to the International Day of Light. The registration deadline for the competition is May 1

Ս.թ. ապրիլի 10-ին ժ. 15:00-ին ՀՀ ԳԱԱ նիստերի դահլիճում (Բաղրամյան պող., 24) տեղի կունենա սեմինարների շարքի երրորդ հանդիպումը՝ «Հավաքում ենք փաթիլ. ատոմներից դեպի մոլեկուլ և բյուրեղ» խորագրով: Որպես մոդերատոր հանդես կգա անվանի քիմիկոս, SKOLKOVO-ի գիտության և տեխնոլոգիաների ինստիտուտի պրոֆեսոր Արտեմ Օհանովը

On April 5 2024, a seminar on the topic "Advanced channeling Technologies: Strong external Electromagnetic fields to guide charged and Neutral Beams" will be held at the conference hall of the NAS RA Presidum which will be presented by professor of the Institute of Nuclear Physics (Italy) Sultan Dabagov

On April 1st 2024, a seminar on the topic "Magnetometry with nuclear spin-polarized 14N in NV centers in diamond" will be held at the conference hall of the RA NAS Presidium which will be presented by professor of the University of Latvia Marcis Auzinsh

The Shirak Center for Armenological Studies of NAS RA is starting to publish the 1 (27) volume of the "Scientific Works" journal for 2024. Priority is given to articles in English and Russian. The deadline for receiving articles is March 1, 2024

Международный инновационный центр нанотехнологий СНГ (МИЦНТ СНГ) при поддержке Межгосударственного фонда гуманитарного сотрудничества государств - участников СНГ (МФГС) и Объединенного института ядерных исследований объявляет о проведении конкурса на соискание грантов на разработку проектов в рамках деятельности МИЦНТ СНГ в 2024 году и очередной Стажировки молодых ученых и специалистов стран СНГ в Дубне в апреле - мае 2024года

ՀՀ գիտության և տեխնիկայի զարգացման 2020-2024թթ. գերակայության ՀՀ կառավարության որոշման նախագիծ

Publications in Press
15/04/2024

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escs.am
12/04/2024

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12/04/2024

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11/04/2024

Արցախի՝ աղվանական ներկայացվող կոթողները որևէ կապ չունեն աղվանների և կովկասյան բնիկ հանրույթների հետ․ Monument Watch
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